Synuclein Antibody ~ Definition : Overview and Research Papers on Synuclein Antibody

Synuclein Antibody ~ Definition : Overview and Research Papers on Synuclein Antibody

Synucleins are a family of soluble proteins common to vertebrates, primarily expressed in neural tissue and in certain tumors.

Alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of

Research Papers on Synuclein Antibody

Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation

Bobby Thomas, Allen S. Mandir, Neva West, Ying Liu, Shaida A. Andrabi, Wanda Stirling, Valina L. Dawson, Ted M. Dawson, Michael K. Lee

PLoS One. 2011; 6(1): e16706. Published online 2011 January 31. doi: 10.1371/journal.pone.0016706

α-Synuclein and Its A30P Mutant Affect Actin Cytoskeletal Structure and Dynamics

Vítor L. Sousa, Serena Bellani, Maila Giannandrea, Malikmohamed Yousuf, Flavia Valtorta, Jacopo Meldolesi, Evelina Chieregatti

Mol Biol Cell. 2009 August 15; 20(16): 3725–3739. doi: 10.1091/mbc.E08-03-0302

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-SynucleinTransgenic Model of Lewy Body Disease

Eliezer Masliah, Edward Rockenstein, Michael Mante, Leslie Crews, Brian Spencer, Anthony Adame, Christina Patrick, Margarita Trejo, Kiren Ubhi, Troy T. Rohn, Sarah Mueller-Steiner, Peter Seubert, Robin Barbour, Lisa McConlogue, Manuel Buttini, Dora Games, Dale Schenk

PLoS One. 2011; 6(4): e19338. Published online 2011 April 29. doi: 10.1371/journal.pone.0019338

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

Latha Devi, Vijayendran Raghavendran, Badanavalu M. Prabhu, Narayan G. Avadhani, Hindupur K. Anandatheerthavarada

J Biol Chem. 2008 April 4; 283(14): 9089–9100. doi: 10.1074/jbc.M710012200

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

He-Jin Lee, Ji-Eun Suk, Christina Patrick, Eun-Jin Bae, Ji-Hoon Cho, Sangchul Rho, Daehee Hwang, Eliezer Masliah, Seung-Jae Lee

J Biol Chem. 2010 March 19; 285(12): 9262–9272. Published online 2010 January 13. doi: 10.1074/jbc.M109.081125

Localization of Synucleins in the Mammalian Cochlea

O. Akil, C. M. Weber, S. N. Park, N. Ninkina, V. Buchman, L. R. Lustig

J Assoc Res Otolaryngol. 2008 December; 9(4): 452–463. Published online 2008 July 30. doi: 10.1007/s10162-008-0134-y

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Lydia Alvarez-Erviti, Yiqi Seow, Anthony H. Schapira, Chris Gardiner, Ian L. Sargent, Matthew J.A. Wood, J. Mark Cooper

Neurobiol Dis. 2011 June; 42(3): 360–367. doi: 10.1016/j.nbd.2011.01.029

Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein

Sharareh Emadi, Srinath Kasturirangan, Min S. Wang, Philip Schulz, Michael R. Sierks

J Biol Chem. 2009 April 24; 284(17): 11048–11058. doi: 10.1074/jbc.M806559200

Isolation of a human single chain antibody fragment against oligomeric α-synuclein that inhibits aggregation and prevents α-synuclein induced toxicity

Sharareh Emadi, Hedieh Barkhordarian, Min S. Wang, Philip Schulz, Michael R. Sierks

J Mol Biol. Author manuscript; available in PMC 2008 February 8.

Published in final edited form as: J Mol Biol. 2007 May 11; 368(4): 1132–1144. Published online 2007 March 7.doi: 10.1016/j.jmb.2007.02.089

α-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport in Mammalian Cells by Antagonizing ER/Golgi SNAREs

Nandhakumar Thayanidhi, Jared R. Helm, Deborah C. Nycz, Marvin Bentley, Yingjian Liang, Jesse C. Hay

Mol Biol Cell. 2010 June 1; 21(11): 1850–1863. doi: 10.1091/mbc.E09-09-0801

Parkinson's Disease-Related Protein, α-Synuclein, in Malignant Melanoma

Yasuhiro Matsuo, Tetsu Kamitani

PLoS One. 2010; 5(5): e10481. Published online 2010 May 5. doi: 10.1371/journal.pone.0010481

ALPHA-SYNUCLEIN-IMMUNOPOSITIVE MYENTERIC NEURONS AND VAGAL PREGANGLIONIC TERMINALS: AUTONOMIC PATHWAY IMPLICATED IN PARKINSON’S DISEASE?

Robert J. Phillips, Gary C. Walter, Sarah L. Wilder, Elizabeth A. Baronowsky, Terry L. Powley

Neuroscience. Author manuscript; available in PMC 2009 May 15.

Published in final edited form as: Neuroscience. 2008 May 15; 153(3): 733–750. Published online 2008 March 18.doi: 10.1016/j.neuroscience.2008.02.074

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

Preeti J Khandelwal, Sonya B Dumanis, Li Rebekah Feng, Kathleen Maguire-Zeiss, GW Rebeck, Hilal A Lashuel, Charbel EH Moussa

Mol Neurodegener. 2010; 5: 47. Published online 2010 November 4. doi: 10.1186/1750-1326-5-47

γ-Synuclein as a marker of retinal ganglion cells

Irina Surgucheva, Alejandra D. Weisman, Jeffrey L. Goldberg, Alexander Shnyra, Andrei Surguchov

Mol Vis. 2008; 14: 1540–1548. Published online 2008 August 22.

α-Synuclein mediates alterations in membrane conductance: a potential role for α-synuclein oligomers in cell vulnerability

Li Rebekah Feng, Howard J. Federoff, Stefano Vicini, Kathleen A. Maguire-Zeiss

Eur J Neurosci. Author manuscript; available in PMC 2011 July 1.

Published in final edited form as: Eur J Neurosci. 2010 July; 32(1): 10–17. Published online 2010 June 14.doi: 10.1111/j.1460-9568.2010.07266.x

Lysosomal Degradation of α-Synuclein in Vivo

Sally K. Mak, Alison L. McCormack, Amy B. Manning-Boğ, Ana Maria Cuervo, Donato A. Di Monte

J Biol Chem. 2010 April 30; 285(18): 13621–13629. Published online 2010 March 3. doi: 10.1074/jbc.M109.074617

Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy

Margot Fournier, Jérémie Vitte, Jérôme Garrigue, Dominique Langui, Jean-Philippe Dullin, Françoise Saurini, Naïma Hanoun, Fernando Perez-Diaz, Fabien Cornilleau, Chantal Joubert, Héctor Ardila-Osorio, Sabine Traver, René Duchateau, Cécile Goujet-Zalc, Katerina Paleologou, Hilal A. Lashuel, Christian Haass, Charles Duyckaerts, Charles Cohen-Salmon, Philipp J. Kahle, Michel Hamon, Alexis Brice, Olga Corti

PLoS One. 2009; 4(8): e6629. Published online 2009 August 14. doi: 10.1371/journal.pone.0006629

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

Ashley R. Winslow, Chien-Wen Chen, Silvia Corrochano, Abraham Acevedo-Arozena, David E. Gordon, Andrew A. Peden, Maike Lichtenberg, Fiona M. Menzies, Brinda Ravikumar, Sara Imarisio, Steve Brown, Cahir J. O’Kane, David C. Rubinsztein

J Cell Biol. 2010 September 20; 190(6): 1023–1037. doi: 10.1083/jcb.201003122

Pathological Modifications of α-Synuclein in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Treated Squirrel Monkeys

Alison L. McCormack, Sally K. Mak, Maryam Shenasa, William J. Langston, Lysia S. Forno, Donato A. Di Monte

J Neuropathol Exp Neurol. Author manuscript; available in PMC 2009 September 16.

Published in final edited form as: J Neuropathol Exp Neurol. 2008 August; 67(8): 793–802.doi: 10.1097/NEN.0b013e318180f0bd

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

Evangelia Emmanouilidou, Dimitris Elenis, Themis Papasilekas, Georgios Stranjalis, Kyriaki Gerozissis, Penelopi C. Ioannou, Kostas Vekrellis

PLoS One. 2011; 6(7): e22225. Published online 2011 July 14. doi: 10.1371/journal.pone.0022225

Transglutaminase-mediated Intramolecular Cross-linking of Membrane-bound α-Synuclein Promotes Amyloid Formation in Lewy Bodies

Zoltán Nemes, Goran Petrovski, Maarten Aerts, Kjell Sergeant, Bart Devreese, László Fésüs

J Biol Chem. 2009 October 2; 284(40): 27252–27264. Published online 2009 August 3. doi: 10.1074/jbc.M109.033969

Drosophila Histone Deacetylase 6 Protects Dopaminergic Neurons against α-Synuclein Toxicity by Promoting Inclusion Formation

Guiping Du, Xiang Liu, Xinping Chen, Mei Song, Yan Yan, Renjie Jiao, Chih-chen Wang

Mol Biol Cell. 2010 July 1; 21(13): 2128–2137. doi: 10.1091/mbc.E10-03-0200

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

Nelson B. Cole, Diane DiEuliis, Paul Leo, Drake C. Mitchell, Robert L. Nussbaum

Exp Cell Res. Author manuscript; available in PMC 2009 June 10.

Published in final edited form as: Exp Cell Res. 2008 June 10; 314(10): 2076–2089. Published online 2008 March 28.doi: 10.1016/j.yexcr.2008.03.012

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

Zhen Hong, Min Shi, Kathryn A. Chung, Joseph F. Quinn, Elaine R. Peskind, Douglas Galasko, Joseph Jankovic, Cyrus P. Zabetian, James B. Leverenz, Geoffrey Baird, Thomas J. Montine, Aneeka M. Hancock, Hyejin Hwang, Catherine Pan, Joshua Bradner, Un J. Kang, Poul H. Jensen, Jing Zhang

Brain. 2010 March; 133(3): 713–726. Published online 2010 February 15. doi: 10.1093/brain/awq008

A Cellular Model To Monitor Proteasome Dysfunction by α-Synuclein

Takashi Nonaka, Masato Hasegawa

Biochemistry. 2009 August 25; 48(33): 8014–8022. Published online 2009 July 24. doi: 10.1021/bi900619j

Synphilin-1A Inhibits Seven in Absentia Homolog (SIAH) and Modulates α-Synuclein Monoubiquitylation and Inclusion Formation

Raymonde Szargel, Ruth Rott, Allon Eyal, Joseph Haskin, Vered Shani, Livia Balan, Herman Wolosker, Simone Engelender

J Biol Chem. 2009 April 24; 284(17): 11706–11716. doi: 10.1074/jbc.M805990200

γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse protein

Natalia Ninkina, Owen Peters, Steven Millership, Hatem Salem, Herman van der Putten, Vladimir L. Buchman

Hum Mol Genet. 2009 May 15; 18(10): 1779–1794. Published online 2009 February 26. doi: 10.1093/hmg/ddp090

α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra

Alison L. McCormack, Sally K. Mak, Jaimie M. Henderson, David Bumcrot, Matthew J. Farrer, Donato A. Di Monte

PLoS One. 2010; 5(8): e12122. Published online 2010 August 11. doi: 10.1371/journal.pone.0012122

ALPHA-SYNUCLEIN IMMUNOPOSITIVE AGGREGATES IN THE MYENTERIC PLEXUS OF THE AGING FISCHER 344 RAT

Robert J. Phillips, Gary C. Walter, Brittany E. Ringer, Katherine M. Higgs, Terry L. Powley

Exp Neurol. Author manuscript; available in PMC 2010 November 1.

Published in final edited form as: Exp Neurol. 2009 November; 220(1): 109–119. Published online 2009 August 5.doi: 10.1016/j.expneurol.2009.07.025

Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis

James H. Soper, Victoria Kehm, Christopher G. Burd, Vytas A. Bankaitis, Virginia M.-Y. Lee

J Mol Neurosci. Author manuscript; available in PMC 2011 August 1.

Published in final edited form as: J Mol Neurosci. 2011 March; 43(3): 391–405. Published online 2010 October 2.doi: 10.1007/s12031-010-9455-5

A pathologic cascade leading to synaptic dysfunction in α-synuclein-induced neurodegeneration

David A. Scott, Iustin Tabarean, Yong Tang, Anna Cartier, Eliezer Masliah, Subhojit Roy

J Neurosci. Author manuscript; available in PMC 2010 December 1.

Published in final edited form as: J Neurosci. 2010 June 16; 30(24): 8083–8095. doi: 10.1523/JNEUROSCI.1091-10.2010

Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Aβ antibodies

Qingyou Li, Marcia Gordon, Chuanhai Cao, Kenneth E Ugen, Dave Morgan

BMC Neurosci. 2007; 8: 22. Published online 2007 March 20. doi: 10.1186/1471-2202-8-22

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein

Paula Desplats, He-Jin Lee, Eun-Jin Bae, Christina Patrick, Edward Rockenstein, Leslie Crews, Brian Spencer, Eliezer Masliah, Seung-Jae Lee

Proc Natl Acad Sci U S A. 2009 August 4; 106(31): 13010–13015. Published online 2009 July 27.doi: 10.1073/pnas.0903691106

Correction in: 

Proc Natl Acad Sci U S A. 2009 October 13; 106(41): 17606.

Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

João Paulo L Daher, Mingyao Ying, Rebecca Banerjee, Rebecca S McDonald, Myriam Dumas Hahn, Lichuan Yang, M Flint Beal, Bobby Thomas, Valina L Dawson, Ted M Dawson, Darren J Moore

Mol Neurodegener. 2009; 4: 34. Published online 2009 July 24. doi: 10.1186/1750-1326-4-34

Synphilin-1 attenuates neuronal degeneration in the A53T α-synuclein transgenic mouse model

Wanli W. Smith, Zhaohui Liu, Yideng Liang, Naoki Masuda, Debbie A. Swing, Nancy A. Jenkins, Neal G. Copeland, Juan C. Troncoso, Mikhail Pletnikov, Ted M. Dawson, Lee J. Martin, Timothy H. Moran, Michael K. Lee, David R. Borchelt, Christopher A. Ross

Hum Mol Genet. 2010 June 1; 19(11): 2087–2098. Published online 2010 February 25. doi: 10.1093/hmg/ddq086

Expression of γ-synuclein in colorectal cancer tissues and its role on colorectal cancer cell line HCT116

Qing Ye, Bo Feng, Yuan-Fei Peng, Xue-Hua Chen, Qu Cai, Bei-Qin Yu, Liang-Hui Li, Ming-Yuan Qiu, Bing-Ya Liu, Min-Hua Zheng

World J Gastroenterol. 2009 October 28; 15(40): 5035–5043. Published online 2009 October 28.doi: 10.3748/wjg.15.5035

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

Yien-Ming Kuo, Zhishan Li, Yun Jiao, Nathalie Gaborit, Amar K. Pani, Bonnie M. Orrison, Benoit G. Bruneau, Benoit I. Giasson, Richard J. Smeyne, Michael D. Gershon, Robert L. Nussbaum

Hum Mol Genet. 2010 May 1; 19(9): 1633–1650. Published online 2010 January 27. doi: 10.1093/hmg/ddq038

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease

Pablo Garcia-Reitböck, Oleg Anichtchik, Arianna Bellucci, Mariangela Iovino, Chiara Ballini, Elena Fineberg, Bernardino Ghetti, Laura Della Corte, PierFranco Spano, George K. Tofaris, Michel Goedert, Maria Grazia Spillantini

Brain. 2010 July; 133(7): 2032–2044. Published online 2010 June 9. doi: 10.1093/brain/awq132

Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies

Xiaoling Wang, Tapan K Das, Satish K Singh, Sandeep Kumar

MAbs. 2009 May-Jun; 1(3): 254–267.

Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats

Zhongwang Yu, Xiaohui Xu, Zhenghua Xiang, Jianfeng Zhou, Zhaohuan Zhang, Chun Hu, Cheng He

PLoS One. 2010; 5(4): e9956. Published online 2010 April 8. doi: 10.1371/journal.pone.0009956